3-HO-PCP HCl

Discover the Potent Dissociative Effects of 3-HO-PCP HCl

3-HO-PCP HCl, or 3-Hydroxyphencyclidine Hydrochloride, is a powerful dissociative substance that produces profound dissociative, hallucinogenic, and euphoric effects.

This novel arylcyclohexylamine compound not only acts as an NMDA receptor antagonist but also exhibits affinity for the μ-opioid receptor, leading to its unique and potent effects.

Pharmacology and History

3-HO-PCP was first synthesized in 1978 to investigate the structure-activity relationship of phencyclidine (PCP) derivatives.

In the 1980s, it was further explored alongside PCP, where it was discovered to possess μ-opioid agonist activity in animal models.

The compound’s potency is significantly higher than that of PCP, and it has been estimated to have analgesic activity one order of magnitude lower than morphine.

Subjective Effects

Like other substances in its class, such as methoxetamine (MXE), phencyclidine (PCP), and 3-MeO-PCE, 3-HO-PCP is known to induce a state referred to as “dissociative anesthesia.

” However, the extent to which this occurs is highly dose-dependent and variable in its effects.

Some reports suggest that 3-HO-PCP may produce more physical side effects, such as muscle soreness and flu-like symptoms, during or shortly after administration, indicating that it may be uniquely more dangerous or toxic than related dissociatives, particularly at higher doses.

Harm Reduction and Legal Status

Due to its sensitive dose-response, potential habit-forming properties, and unknown toxicity profile, it is strongly recommended to use proper harm reduction practices if choosing to use this substance. 3-HO-PCP is almost exclusively distributed as a gray area research chemical by online vendors, and extremely little is known about its pharmacology, metabolism, and toxicity in humans.

In the UK, the Advisory Council on the Misuse of Drugs released a report in 2012 suggesting that all analogs of methoxetamine (MXE), including 3-HO-PCP, should become Class B drugs under the Misuse of Drugs Act 1971.

FAQs

1. What is the legal status of 3-HO-PCP?
   3-HO-PCP is considered a gray area research chemical and is not scheduled in most countries.
2. However, it may fall under analogue laws or be considered controlled substances in some jurisdictions.
3. Is 3-HO-PCP safe to use?
   The safety and toxicity profile of 3-HO-PCP are largely unknown due to the lack of research.
4. It is a potent substance with a sensitive dose-response, and its effects can be variable and potentially dangerous, especially at higher doses.
5. How does 3-HO-PCP compare to other dissociatives?
   3-HO-PCP is significantly more potent than PCP and exhibits unique properties, such as its affinity for the μ-opioid receptor. However, it shares similarities with other dissociatives in its ability to induce a “dissociative anesthesia” state.
6. What are the potential risks of using 3-HO-PCP?
   Potential risks include physical side effects like muscle soreness and flu-like symptoms, as well as the unknown long-term effects and toxicity of the substance.
7. There is also a risk of addiction and habit formation due to its potency and unique effects.
8. How should 3-HO-PCP be stored?
   3-HO-PCP HCl should be stored in a cool, dry place away from direct sunlight and moisture, ideally between 20-25°C. Proper storage techniques, such as vacuum sealing, can help maintain the compound’s quality and potency.

Remember, 3-HO-PCP is a potent and understudied substance.

Always exercise caution, use proper harm reduction techniques, and consult with medical professionals before considering the use of any novel psychoactive substances.